An anti-H1N1 virus extract of compound herbs is provided. The composition of the compound herbs essentially consisting of 1-3 parts by weight of Lonicera japonica Thunb., Gynostema pentaphyllum (Thunb.) Markino, Sophora subprostarta chun et T. Chen, Houttuynia cordata Thunberg, Arctium lappa L., Mentha arvensis L. var. piperascens Malinv., and C. cuneata Sieb. et Zucc. 1-2 parts by weight of Perilla frutescens (L.) Britt. Var crispa (Thunb.) Hand.-Mazz. and Perilla frutescens (L.) Britton, and Sterculia scaphigera Wall. as well as 0.5-1.5 parts by weight of Platycodon grandiflorum (Jacquin)A. DC., Pogostemon cablin (Blanco) Benth., Glycyrrhiza uralensis Fisch et DC., and Zingiber officinale Rosc. Moreover, some oral formulations and preparation methods thereof are also provided.提供一種抗流感病毒H1N1複方藥材之萃取物。上述複方藥材的組成基本上包括1-3重量份之金銀花、絞股藍、山豆根、魚腥草、牛蒡子、薄荷及山楂,1-2重量份之紫蘇及胖大海,以及0.5-1.5重量份之桔梗、藿香、甘草及薑。另外還提供含有上述萃取物之口服劑型與其製備方法。C‧‧‧空白組V‧‧‧病毒對照組S1‧‧‧樣品濃度10μg/ml組S2‧‧‧樣品濃度30μg/ml組S3‧‧‧樣品濃度100μg/ml組S4‧‧‧樣品濃度300μg/ml組