HORN, CARSTEN,ZOLLNER, SABINE,METZNER, HUBERT,SCHULTE, STEFAN
申请号：
HK14112047.2
公开号：
HK1198541A
申请日:
2014.11.28
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The present invention relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising essentially the A1 domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing of the Factor VIII molecule. The invention further pertains to a method for improving the bioavailability of Factor VIII after intravenous and non-intravenous injection.
