KO, Sang Woon,고상운,CHOI, Hack Sun,최학선,KIM, Jihyang,김지향,KIM, Sulim,김수림,JUNG, Dong Kee,정동기
申请号：
KRKR2016/011209
公开号：
WO2018/021618A1
申请日:
2016.10.06
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to: a composition and an aromatic composition, which are for inhibiting the growth of cancer stem cells and contain, as an active ingredient, cis-3-hexenal or a pharmaceutically acceptable salt thereof and a pharmaceutical composition, food composition, and the like, which are for inhibiting cancer metastasis or for treating or preventing cancer and contain the composition. Cis-3-hexenal of the present invention inhibits the growth of breast and lung cancer cells and inhibits the formation of breast and lung cancer stem cells. In addition, cis-3-hexenal of the present invention has been confirmed to inhibit the expression of self-renewal genes, such as Nanog, C-myc, Oct4, and CD44, which are known to be distinctively expressed in breast cancer stem cells, inhibit the production of IL-6, which is known to be involved in the formation of mammospheres of breast cancer stem cells, and inhibit the STAT3 signaling pathway. Furthermore, cis-3-hexenal has been confirmed to inhibit the production of IL-8, which is known to be involved in the formation of tumorspheres of lung cancer stem cells, and inhibit the NF-κB signaling pathway. Therefore, the compound inhibits the growth of stem cells of cancer such as breast and lung cancer and inhibits the growth of the cancer, thereby being usable in the treatment of cancer such as breast and lung cancer.La présente invention porte sur un composé aromatique destiné à inhiber la croissance de cellules souches cancéreuses. Il contient du cis-3-hexénal, ou un sel pharmacologiquement comparable de celui-ci, un composé pharmaceutique et alimentaire destinée à inhiber les métastases, traiter ou prévenir le cancer. Le cis-3-hexénal supprime la croissance des cellules mammaires et colorectales, et inhibe la formation de leur cellules souches. Le cis-3-hexénal inhibe lexpression de gènes dauto-renouvellement, tels que le Nanog, C-myc, Oct4 et CD44, qui sont exprimés dans les cellules souches du cancer du sein. I
