Disclosed are various embodiments of a surgical instrument for colorectal polyp removal. In various embodiment, the surgical instrument has an elongate flexible tubular sheath having a proximal end and a distal end, a snare having a loop and controlled by a pair of wires, and a biopsy forceps having a pair of jaws sized to fit within the loop of the snare. Both the biopsy forceps and the snare are routed through the elongate flexible tubular sheath so that the loop of the snare and the pair of jaws exit the distal end of the elongate flexible tubular sheath.