MICHAELIDES, MICHAEL,PENNIG, THOMAS D.,POHLKI, FRAUKE,DOHERTY, GEORGE,KLING, ANDREAS,TAO, ZHI,FU - WANG, XILU,SONG, XIAOHONG,BRAJE, WILFRIED,BRADY, PATRICK,WENDT, MICHAEL D.,JANTOS, KATJA,TESKE, JESSE
申请号：
ARP180102348
公开号：
AR112692A1
申请日:
2018.08.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Compounds that are effective agents for the treatment of diseases and diseases, including cancer. Pharmaceutical synthesis containing these compounds is also provided. 1. Characteristic 1: a formula compound (1) or a salt which can be extracted from it and accepted,A3 is n, a8308es cr8308； 74919；A8310s is C, or A2,A3 is n, a8308es or s, a8310es C； or N, A3 is C, a8308es or s, a8310es C； or N, A3 is C, a8308es cr8308； a749191；A8310es n； RA is hydrogen, ch832323；Halogen, CN, ch8322； (F, chf832222)；o CF83223；X is O, o n (r739)；where Rˣ² is hydrogen, C₁₋₃ alkyl,O bicycle not replaced； and (CH 8322244)；-CH 3DCH- (CH) -(CH) -CH 3DCH-o - (CH) q-CH 3DCH- (CH) -Among them, 0, 1, 2, or 3 c83222 groups were composed of O, n (r696)； 74919；C (R) (R)it is life.NC (O) Ro S (O)M is 2, 3, 4 or 5； n is 1, 2, or 3； P is 1, 2, or 3； q is 1 or 2； R is 1 or 2； the sum of Q and R is 2 or 3； r6966； 74911；In each case, it is an independent hydrogen, alquenilo c832283331-832626；1. C 83228331 asphalt；G1，1. Lease land No. c833218331 and 832626；or Cal haloalkyl；where the alkenyl C₂₋₆,1. C 83228331 asphalt；1. Lease land No. c833218331 and 832626；and C₁₋₆ haloalkyl are optionally substituted with 1 or 2 substituents selected independently from the group consisting of oxo, -N (Rʸᵈ) (Rʸᵉ),G1，-Or696；-75844；-SR696；-75011；-S (O) N (R) (R)y -S (O) -Gand Rʸᵇ is alkenyl C₂₋₆,1. C 83228331 asphalt；G1，1. Lease land No. c833218331 and 832626；or Cal haloalkyl；where the alkenyl C₂₋₆,1. C 83228331 asphalt；1. Lease land No. c833218331 and 832626；and C₁₋₆ haloalkyl are optionally substituted with 1 or 2 substituents selected independently from the group consisting of oxo, -N (Rʸᵈ) (Rʸᵉ),G1，-Or696；-75844；-SR696；-75011；-S (O) N (R) (R)y -S (O) -GO r696； 7491 and r696； 74955；together with the carbon atom to which they are attached, they form a monocyclic C₃₋₇ cycloalkyl, monocyclic C₄₋₇ cycloalkenyl, or a 4-7 membered monocyclic heterocycle； wherein the monocyclic C₃₋₇ cycloalkyl, monocyclic C₄₋₇ cycloalkenyl, and
