Novel VEGF variant and its use for serving as biological cancer marker capable of quickly and accurately detecting brain cancer occurrence, brain cancer staging, and brain cancer prognosis in vitro
The main purpose of the present invention is to disclose a novel VEGF (vascular endothelial growth factor) isoform and its use, wherein the novel VEGF isoform can be used as a biological marker for the diagnosis, staging and evaluation of prognosis of brain tumors. Therefore, by detecting the performance or the amount of performance of the VEGF isoform in a sample, it is able to quickly and accurately detect brain cancer occurrence, brain cancer staging, and brain cancer prognosis in vitro. The VEGF isoform is provided with an amino acid sequence encoded as being selected from the group consisting of SEQ ID No. 2 and SEQ ID No. 4. When the amino acid sequence of the VEGF isoform is encoded as SEQ ID No. 2, it is translated from nucleotide sequence encoded as SEQ ID No. 1. When the amino acid sequence of the VEGF isoform is encoded as SEQ ID No. 4, it is translated from nucleotide sequence encoded as SEQ ID No. 3.本發明之主要目的係在於揭露新穎之VEGF亞型及其用途,其中,該新穎VEGF亞型係能作為腦瘤診斷、分期及評估預後之生物標幟物,因此,藉由檢測樣本中VEGF亞型之表現或其表現量,能夠於體外快速且準確地檢測出腦癌發生、腦癌分期及其預後狀態。
