Biocompatible polymeric coatings, membranes, matrices, and films to be used with implantable medical devices contain a film-forming fluorine-containing homo-polymer or copolymer containing the polymerized residue of a fluorine-containing moiety, wherein the relative amounts of the polymerized residues of one or more moieties are effective to provide the coating and films with properties effective for use in coating implantable med devices.