Provided is a method for weeds control, which comprises transferring a nucleotide sequence encoding thifensulfuron-methyl hydrolysis enzyme to a plant genome； when compared with a control plant, the transgenic plant has alleviated plant damage and/or increased plant yield； further applying a herbicide containing an effective amount of tribenuron-methyl to a growing environment of the transgenic plant, as the thifensulfuron-methyl hydrolysis enzyme has a relatively high tolerance to the tribenuron-methyl herbicide, weeds control can be achieved.
