The present invention discloses a kind of for reducing local fat and the composition and its pharmaceuticals that reduce weight and application,The composition includes the resveratrol and turmeric extract that weight ratio is 1: 30 to 10: 1,Composition and its pharmaceuticals of the present invention can inhibit adipocytic cell growth,And the apoptosis for causing fat cell planned,Reach reduction fat cell,It reduces localized fat deposits and reduces the effect of weight,Inflammatory response or tissue necrosis without causing periphery cell and tissue,Also inflammation or pain reaction without peripheral organization,And then avoid the prior art using tissue damaged and inflammation pain problem caused by the fat melting instrument of liposuction or low intrusion,It there will not be fat melting injection ingredient phosphatidyl choline(phosphatidylcholine)Or NaTDC(sodium deoxycholate)Cause cell disruption downright bad(necrosis)The problems such as peripheral organizations inflammation and necrosis caused is infected.