POLYPEPTIDE DE FUSION DIRIGÉ CONTRE UNE TUMEUR INDUITE PAR LE VIRUS EB ET MUTANT DE LA COLICINE IA

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专利权人:

LTD.;PROTEIN DESIGN LAB

发明人:

QIU, XIAOQING

申请号：

EP10836940

公开号：

EP2514768A4

申请日:

2010.02.26

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention provides a fusion polypeptide against EB virus-induced tumor, which comprises an antibody or a mimetic antibody against EB virus and an ion channel forming colicin selected form E1. Ia, Ib, A, B, N and their mutants. The present invention also provides a colicin Ia mutant, which comprises mutations of G11A, H22G, A26G, V31L, and H40D. The present invention also provides a gene, vector, preparation method and use of the fusion polypeptide, and provides a gene and use of the mutant.

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