Those where it is disclosed with this bill, the chronic kidney disease, and/or, are the composition in order to remedy metabolism imbalance and method. Concretely, as for those where it is illustrated with this bill, one nitrogen oxide (NO) of the endothelium, or, also the combined use medicine and the RAS obstruction medicine and those where performance of the endothelium is improved it is the method of including dosage. In addition, metabolic syndrome 1 or it seems like plural diagnostic standards, the method of remedying the patient who shows at least one of condition of one stage of the chronic kidney disease, and the condition of metabolism imbalance is disclosed.< Selective figure > It is not本明細書で開示されるのは、慢性腎疾患、及び/又は、代謝不均衡を治療するための組成物及び方法である。具体的には、本明細書で例示されるのは、内皮の一酸化窒素(NO)、又は、内皮の機能を改善する併用薬剤と、RAS阻害薬との共投与を含む方法である。また、メタボリック症候群の1又は複数の診断基準のような、慢性腎疾患の1つの段階の症状、及び、代謝不均衡の症状の少なくとも1つを示す患者を治療する方法が開示される。【選択図】 なし