Anthony O. Caggiano,Elliott A. Gruskin,Yelena G. Sheptovitsky,Sarah Kasperbauer
申请号：
US11568831
公开号：
US08226941B2
申请日:
2005.05.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.
