AKTOUDIANAKIS, EVANGELOS,CHIN, GREGORY,CORKEY, BRITTON KENNETH,DU, JINFA,ELBEL, KRISTYNA,JIANG, ROBERT H.,KOBAYASHI, TETSUYA,LEE, RICK,MARTINEZ, RUBEN,METOBO, SAMUEL E.,MISH, MICHAEL,MUNOZ, MANUEL,SHE
申请号：
SG11201509220X
公开号：
SG11201509220XA
申请日:
2014.05.08
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.本發明係有關可用作為含溴結構域的蛋白質(包括含溴結構域的蛋白質4(BRD4))的抑制劑,或另一方面可調節該含溴結構域的蛋白質的活性之化學化合物,及有關含此化合物的組成物和調合物,及使用和製造此化合物的方法。所述之化合物包含式(I)所示化合物,其中R1a、R1b、R2a、R2b、R3、R4a、R4b、和R5係如文中所述。
