VIB VZW;UNIVERSITEIT GENT;TRUSTEES OF DARTMOUTH COLLEGE;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
SAELENS, Xavier,SCHEPENS, Bert,ROSSEY, Iebe,GRAHAM, Barney,MCLELLAN, Jason,GILMAN, Morgan
申请号:
CL2017003260
公开号:
CL2017003260A1
申请日:
2017.12.18
申请国别(地区):
CL
年份:
2018
代理人:
摘要:
<;p>; THE PRESENT INVENTION REFERS TO SIMPLE VARIABLE IMMUNOGLOBULIN DOMAINS (ISVDS) THAT ARE DIRECTED AGAINST RESPIRATORY SYNCITIAL VIRUS (RSV). MORE SPECIFICALLY, IT REFERS TO ISVDS THAT BIND WITH THE PREFUSION FORM OF THE RSV FUSION PROTEIN (F). THE INVENTION IS ALSO RELATED TO THE USE OF THESE ISVDS FOR THE PREVENTION AND / OR TREATMENT OF RSV INFECTIONS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THESE ISVDS. <;/p>;<;p>;LA PRESENTE INVENCIÓ;N SE REFIERE A DOMINIOS VARIABLES SIMPLES DE INMUNOGLOBULINA (ISVDS) QUE SE DIRIGEN CONTRA VIRUS SINCICIAL RESPIRATORIO (RSV). MÁ;S ESPECÍ;FICAMENTE, SE REFIERE A ISVDS QUE SE UNEN CON LA FORMA DE PREFUSIÓ;N DE LA PROTEÍ;NA DE FUSIÓ;N (F) DE RSV. LA INVENCIÓ;N TAMBIÉ;N SE REFIERE AL USO DE ESTOS ISVDS PARA LA PREVENCIÓ;N Y/O EL TRATAMIENTO DE INFECCIONES POR RSV Y S COMPOSICIONES FARMACÉ;UTICAS QUE COMPRENDEN ESTOS ISVDS.<;/p>;