Hanping FENG,Yongjun GUAN,Yongrong ZHANG,Zhiyong YANG,Lianfa SHI
申请号：
US15548901
公开号：
US20180244760A1
申请日:
2016.02.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.
