Compositions for reducing the frequency of urination are disclosed. One aspect of the present invention provides a pharmaceutical composition for reducing the frequency of urination, comprising: a first analgesic agent selected from the group consisting of aspirin, ibuprofen, naproxen sodium, indomethacin, nabumetone and acetaminophen, wherein said pharmaceutical composition is formulated in an extended-release formulation and wherein said first analgesic agent is administered orally at a daily dose of 5 mg to 2000 mg. A further aspect provides a pharmaceutical composition for reducing the frequency of urination, comprising: a first component formulated for immediate-release； and a second component formulated for extended-release, wherein said first component and said second component each comprises one or more analgesic agents selected from the group consisting of aspirin, ibuprofen, naproxen sodium, indomethacin, nabumetone and acetaminophen, and wherein each analgesic agent in said first component and said second component is administered orally at a daily dose of 5 mg to 2000 mg. Another aspect provides a pharmaceutical composition, comprising: one or more analgesic agents selected from the group consisting of aspirin, ibuprofen, naproxen sodium, indomethacin, nabumetone and acetaminophen； an antidiuretic agent； and a pharmaceutically acceptable carrier, wherein said pharmaceutical composition is formulated for extended-release in an oral dosage form, and wherein the total dosage of said one or more analgesic agents is 5 mg to 1000 mg.
