The present invention relates to Surfactant Protein D (SP-D) or nucleic acids encoding SP-D or variants therof such as surfactant protein A or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of SP-D in a sample are also disclosed. Also disclosed are helminths for treating allergy, inflammation or infection.La présente invention concerne la Protéine Tensioactive D (SP-D) pour une utilisation dans le traitement et/ou la prévention Dune infection parasitaire.