DEMARCO, STEVEN J.,MUKHERJEE, RESHMI,MOEHLE, KERSTIN,ROBINSON, JOHN ANTHONY,HENZE, HEIKO,ROMAGNOLI, BARBARA,OBRECHT, DANIEL,GOMBERT, FRANK,LUDIN, CHRISTIAN,VRIJBLOED, JAN WIM
申请号：
CA2679414
公开号：
CA2679414C
申请日:
2007.02.28
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The template-fixed ß-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro- Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients； or where Cancer is mediated or resulting fromCXCR4 receptor activity； or where immunological diseases are mediated or resulting from CXCR4 receptor activity； or for treating immuno suppression； or, in particular, for stem cell mobilisation of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These .beta.-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.
