The present invention is located in the field of chemical compounds belonging to the group of nucleotide analogues. A subject of the invention is acylnucleoside phosphonate compounds and also the preparation process thereof, and the use thereof as medicaments, especially for preventing and/or treating diseases caused by infection by an organism that is auxotrophic for purines, such as Plasmodium falciparum. Another subject of the invention is pharmaceutical compositions comprising such compounds.