DAVIS ROBERT J,ORBAN GEORGE JOHN,STATON JOHN ALEXANDER
申请号：
NZ59876210
公开号：
NZ598762A
申请日:
2010.08.30
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
The disclosure relates to a reversible oral adhesive gel for securing lips together, the reversible oral adhesive gel comprising: one or more adhesive agents, the oral adhesive in the form of a gel and having a pH of 5.0 or lower, and wherein the adhesive agent or agents are selected from the group consisting of: an alkyl vinyl ether/maleic anhydride copolymer, mixed sodium/calcium salts of methyl vinyl ether/maleic anhydride copolymer and soluble polyvinyl pyrrolidones； and one or more thickener/hydrophobic gelling agents in an amount from about 1wt% to about 10wt%, the one or more thickener/hydrophobic gelling agents selected from the group consisting of xanthan gum, carageenan gum, guar gum, sodium alginate, acacia gum, hydroxypropylcellulose, hydroxypropylmethylcellulose, gelatin, and pectin； wherein the reversible oral adhesive gel has an average maximum stress value of at least 0.01 MPa. Also disclosed is a method of preparing a reversible oral adhesive gel, comprising the steps of: (a) mixing 1.0 gm of disodium edetate, 2.0 gm of potassium sorbate and 20.0 gm of citric acid anhydrous in 547.0 gm of purified water for 10 min at 25°C； (b) adding to the mixture of step (a) 120.0 gm of a calcium/sodium PVM/MA copolymer, avoiding lump formation and mixing until fully dispersed； (c) adding to the mixture of step (b) 100.0 gm of ethanol 95% undenatured, mixing until fully dispersed； (d) adding to the mixture of step (c) 120.0 gm of a soluble polyvinyl pyrrolidone avoiding lump formation and mixing until fully dispersed； (e) adding to the mixture of step (d) 20.0 gm of xanthum gum, avoiding lump formation and mixing until fully dispersed； (f) adding to the mixture of step (e) 45.0 gm of silicon fluid, avoiding lump formation and mixing until fully dispersed； (g) adding to the mixture of step (f) 10.0 gm of silicon dioxide, avoiding lump formation and mixing fully until dispersed； and (h) adding to the mixture of step (g) 15.0 of a polyacrylamide, C13-C14 isoparaffin
