Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
MULLER GEORGE W,SCHAFER PETER H,MAN HON-WAH,GE CHUANSHENG,XU JEAN
申请号：
NZ60066808
公开号：
NZ600668A
申请日:
2008.03.27
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
ABSTRACT - 600668 The disclosure relates to solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione represented by structural formula (I), compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. Particularly disclosed is a solid form comprising the enantiomerically pure compound of formula (I) having an X-ray powder diffraction pattern comprising peaks at about 8.1, 15.2, 17.4, 23.6 and 25.1 degrees 2theta. These solid forms are suitable for treating and/or preventing disorders ameliorated by the reduction of levels of TNF-( or the inhibition of PDE4 and are are used for treating a disease or disorder selected from psoriasis psoriatic arthritis rheumatoid arthritis chronic cutaneous sarcoid giant cell arteritis Parkinsons Disease prurigo nodularis lichen planus complex apthosis Behcets Disease lupus hepatitis uveitis Sjogrens Disease depression interstitial cystitis vulvodynia prostatitis osteoarthritis diffuse large B cell lymphoma polymysoitis dermatomyositis inclusiuon body myositis erosive osteoarthritis interstitial cystitis hepatitis endometriosis radiculopathy and pyoderma gangrenosum, and are also used for treating a disease or disorder is selected from HIV hepatitis adult respiratory distress syndrome bone resorption diseases chronic obstructive pulmonary diseases chronic pulmonary inflammatory diseases dermatitis inflammatory skin disease, atopic dermatitis, cystic fibrosis septic shock sepsis endotoxic shock hemodynamic shock sepsis syndrome post ischemic reperfusion injury meningitis psoriasis fibrotic disease cachexia graft rejection including graft versus host disease auto immune disease rheumatoid spondylitis arthritic conditions, such as rheumatoid arthritis and osteoarthritis osteoporosis Crohns disease ulcerative colitis inflammatory bowel disease multiple sclerosis systemic lupus erythrematosus erythema nodosum leprosum in lepros
