Cornelis G. Kruse;Josephus H. M. Lange;Arnoldus H. J. Herremans;Herman H. Van Stuivenberg
发明人:
Cornelis G. Kruse,Josephus H. M. Lange,Arnoldus H. J. Herremans,Herman H. Van Stuivenberg
申请号：
US12203113
公开号：
US08729101B2
申请日:
2008.09.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I), wherein R and R1-R4 have the meanings given in the specification.
