1. The compound or its pharmaceutical salt, amide or ester with the general formula ZYX is a leptin compound in which Z is an acyl group containing 12-22 carbon atoms and containing a C-terminal carboxylic acid or C-terminal tetrazole group； Y represents a spacer selected from the group consisting of bonds, where m is 0, 1, 2, 3, 4, 5, or 6； n is 1, 2 or 3； s is 0, 1, 2 or 3； p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 or 23； r is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, or 23； X is group for anchoring the leptin compound and represents or “*” indicates the grouping point, which is oriented towards the leptin compound, and “*” ”indicates the grouping point, which is oriented towards Z.2. A compound according to claim 1, wherein the Z-Y-X moiety is bound to the amino group present in the N-terminal alpha-amino group in the leptin compound. The compound of general formula ZYX is a leptin compound in which Z is an acyl group containing 12-22 carbon atoms and containing a C-terminal carboxylic acid or C-terminal tetrazole group； Y is a spacer selected from the group consisting of a bond, and m is 0, 1, 2, 3, 4, 5, or 6； n is 1, 2 or 3； s is 0, 1, 2 or 3； p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 or 23； r is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, or 23.4. The compound according to any one of claims 1, 2 or 3, where Z contains 16-18 carbon atoms, and where Y is a spacer selected from the group consisting of bonds, and m is 0, 1, 2； n is 1, 2 or 3； s is 0, 1, 2 or 3； p is 1, 2, 3 or 4； r is1. Соединение или его фармацевтическая соль, амид или сложный эфир с общей формулой Z-Y-X-лептиновое соединение, в котором Z представляет собой ацильную группу, содержащую 12-22 атома углерода и содержащую C-концевую карбоновую кислоту или C-концевую тетразольную группу；Y представляет собой спейсер, выбранный из группы, состоящей из
