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Method of Cell Differentiation and Uses Therefor in Screening, Diagnosis and Therapy
专利权人:
Colin Tso
发明人:
Colin Tso
申请号:
US13257047
公开号:
US20120171194A1
申请日:
2010.03.08
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a method of producing non-haematopoietic cells, in particular cells having one or more properties of endothelial cells, from monocytes. A range of diagnostic and prognostic assay methods for determining whether or not a subject has atherosclerosis or vascular complication associated therewith, or a predisposition for developing atherosclerosis or complication associated therewith employing this method are provided. A range of screens to identify and isolate compositions of matter that modulate the ability of monocytes to differentiate into such non-haematopoietic cells and/or that modulate the ability of such non-haematopoietic cells to become incorporated into endothelium e.g., vascular endothelium, are also provided.
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