BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
BROWN, LARRY R.,GIANNOUKAKIS, NICK,GILLIS, KIMBERLY A.
申请号：
CA2657517
公开号：
CA2657517C
申请日:
2007.08.06
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
AS-oIigonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
