KIM HONG WOO,KOH JONG SUNG,LEE JAEKYOO,SONG HO-JUHN,KIM YOUNGSAM,LEE HEE KYU,CHOI JANG-SIK,LIM SUN-HEE,CHANG SUNHWA,KIM JUNG-HO,KIM SE-WON
申请号：
ZA201204246
公开号：
ZA201204246B
申请日:
2012.06.11
申请国别(地区):
ZA
年份:
2013
代理人:
摘要：
The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.
