UNIVERSITE CLAUDE BERNARD - LYON 1;UNIVERSITE D'AIX-MARSEILLE;CENTRE LEON BERARD;INSTITUT JEAN PAOLI & IRENE CALMETTES;INSERM (INSTUTUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
发明人:
FAGET JULIEN,MENETRIER-CAUX CHRISTINE,OLIVE DANIEL,CAUX CHRISTOPHE,NUNES JACQUES
申请号：
ZA201306656
公开号：
ZA201306656B
申请日:
2013.09.04
申请国别(地区):
ZA
年份:
2015
代理人:
摘要：
The present invention provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFN³ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. The present invention also relates to uses of said antibodies for treating autoimmune diseases, transplantation rejection and graft versus host disease."
