600721 A seamless capsule comprising a liquid pharmaceutically active ingredient and one or more kinds of solid pharmaceutically active ingredients, wherein the liquid pharmaceutically active ingredient is encapsulated in the form of a liquid pharmaceutical composition, and the solid pharmaceutically active ingredient is applied onto a capsule shell layer free of the pharmaceutically active ingredient, wherein the liquid pharmaceutically active ingredient comprises a ?3-fatty acid ethyl ester, wherein the ?3-fatty acid ethyl ester comprises EPA ethyl ester and DHA ethyl ester, wherein the liquid pharmaceutical composition comprises not less than 40% w/w of EPA ethyl ester and not less than 34% w/w of DHA ethyl ester, and wherein the capsule shell layer is formed from a shell composition comprising glycerin and sorbitol as plasticizers.
