Embodiments of the invention include a handpiece system including a detachable cable that can receive at least power, and a detachable cable connector, where the detachable cable connector and detachable cable are reversibly attachable to each other. In some embodiments, the system includes an interchangeable laser module, where the laser module and detachable cable connector are reversibly attachable to each other. Further, the interchangeable laser module is configured and arranged to receive at least the power via the cable connector when coupled to the cable connector, and to be removed from the detachable cable connector and replaced with another laser module. In some embodiments, the system further includes an interchangeable handpiece which is reversibly attachable to the interchangeable laser module. Further, the interchangeable handpiece is configured and arranged to be removed from the interchangeable laser module and replaced with another interchangeable handpiece.