Compounds derived from triazolopiridina Hydrogenated P2X7 Inhibitors, Pharmaceutical composition that comprises； Preparation Process； and their use in the treatment of Bone Diseases,SNS, cardiovascular, among others (Divisional cl 2655 - 2015)
COATE HEATHER R.,DVORAK CURT A.,GELIN CHRISTINE F.,ALCAZAR VACA MANUEL JESUS,ALLISON BRETT D.,ANDRES GIL JOSE IGNACIO,DE ANGELIS MERI,DENG XIAOHU,LIANG JIMMY T.,RECH JASON C.,SAVALL BRAD M.,SOYODE-JOH,COATE HEATHER R,DVORAK CURT A,GELIN CHRISTINE F,ALLISON BRETT D,ANDRES GIL JOSE
申请号：
CL2017002610
公开号：
CL2017002610A1
申请日:
2017.10.16
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
1. This document refers to: ADEM amp； Aacute； s, pharmacology and amp； eacute； uticas que lt； br / gt；comprenden los compuestos de las f 26amp oacute rmulas (1 1a 2a y 2b) Los m 26amp eacute todos 26lt br 2F 26gt1. Preparation and use of F amp； oacute； RMFs (1, 1a, 2a and 2b) lt； br / gt compounds；These claims are within the scope of this report, ADEM amp； Aacute； s. Disease, disease, disease, diseaseAutoimmunity. 1. Rejorci amp； oacute； n 1: F amp compound； oacute； rmula (1), where lt； br / gt；R1 is (a) phenyl, which can be substituted by zero into four groups； br / gt；a. Any kind of personnel selected from the halo group, asphalt and fabric； br / gt；C1-4, Alcoy, perhaloteoqui and perhalacloxi； O (b) heteromorphism, lt； br / gt；The group consisting of lt； br / gt remains was selected independently；F amp group； oacute group； rmules group (3)； rk independently selects LT group； br / gt group；a. Br / gt； group consisting of H, halo, c1-3, hydroxy, perhalogeo and lt；Alcoxi； rise independently selects h or c1-3 tar, where lt； br / gt；C1-3 EST Aacute； alternative 1-3； br / gt；Halo, a replacement for your Wu or a replacement for alcoxi； n is a complete 0 - lt； br / gt；3. X is n or CRZ； R2 is h, and perchloride tar or tar below C1 amp； mdash； 3； R3 is h, lt； br / gt；1. Over halogenated tar, C1 tar and ampere； mdash； 4, alcalcoxi, ch2r amp； Iacute； - C (o) re or fenilo, containing lt； br / gt；Fenilo EST amp； Aacute； option 2 lt is zero； br / gt；a. Any kind of personnel selected from the halo group, asphalt and fabric； br / gt；C1 amp； mdash； 3, Alcoy, peralogeoquile and peralalcoxi； RI is oh, nc3h6, n (C1 amp； mdash； 3) 2 lt； br / gt；O halo； re is oh, o-asphalt c1-3, n (c1-3 tar) 2, or nc3h6； R4 and R5 are lt； br / gt；Independent of H or C1 and mp； mdash； 3； R8 is phenyl or pyridine, and you can choose lt； br / gt；Replace with zero to four RM replacements, where RM is selected, lt； br
