A liquid spray device includes a container defining a reception space for receiving a liquid medicine therein, having a discharge outlet for discharging the liquid medicine to an exterior of the container a spray module disposed in the discharge outlet, and connected electrically to a driving source such that the liquid medicine forcefully collides against the discharge outlet due to ultrasonic oscillation of the spray module and spraying out a plurality of mist droplets and a particle sorter disposed downstream to a discharging direction of the liquid medicine, spaced from the spray module at a predetermined distance to permit once against collision of the liquid medicine during the discharging operation such that the mist droplets are sprayed out through the particle sorter in terms of a plurality of micro-mist droplets along the discharging direction.
