ANTI-PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (ANTI-PCSK9) COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES
ABDEL-MEGUID, SHERIN SALAHELDIN,ELSHOURBAGY, NABIL,MEYERS, HAROLD,MOUSA, SHAKER A.
申请号：
EP14770138
公开号：
EP2968266A4
申请日:
2014.03.11
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia. Examples of compounds include thiadiazole, isoxazole, 1,2,4-triazole, thiazole, indole, pyrazole, and pyrrolinone derivatives.
