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IMMEDIATE RELEASE DOSAGE FORM
专利权人:
Johnson &; Johnson Consumer Inc.
发明人:
Jitendra Krishan Somani,Murali K. Vuppala
申请号:
US16364244
公开号:
US20200306192A1
申请日:
2019.03.26
申请国别(地区):
US
年份:
2020
代理人:
摘要:
An improved immediate release solid dosage form of naproxen with a certain particle size distribution for the intragranular portion, and a certain particle size distribution for the carbonate portion that allows naproxen to remain in solution and achieves fast dissolution and fast absorption of naproxen. The invention provides a naproxen dosage form that when administered to a human in a fasted state provides an average blood plasma naproxen concentration of at least 15-20 μg/ml in 10 minutes or less. The invention also provides a naproxen dosage form that when administered to a human in a fed state provides an average blood plasma naproxen concentration of at least 15-20 μg/ml in 50 minutes or less.
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