The present disclosure relates generally to treating or preventing diseasesassociated withangiogenesis by administering to a patient certain compounds found to inhibitor substantiallyreduce angiogenesis. Compounds employed according to the present disclosureexhibit goodanti-angiogenic activity as well as demonstrate a prophylactic effect forpreventing andsubstantially reducing angiogenesis. Examples of such compounds includeRitanserin,Amiodarone, Terfenadinc, Perphenazine, Bithionol, and Clomipramine