Hing L. SHAM,Roy K. HOM,Andrei W. KONRADI,Gary D. PROBST,Simeon BOWERS,Anh TRUONG,R. Jeffrey NEITZ,Jennifer SEALY,Gergely TOTH
申请号：
US16653110
公开号：
US20200039972A1
申请日:
2019.10.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
