PROBLEM TO BE SOLVED: To provide a preventing, suppressing or treating agent that has a potency of preventing, suppressing or treating corneal disease or corneal damage.SOLUTION: An agent for preventing, suppressing or treating corneal disease or corneal damage contains, as an effective ingredient, a polypeptide including a region comprising a polypeptide selected from the group consisting of the following (a) to (c): (a) a polypeptide formed from 70 or more continuous amino acids in the amino acid sequence represented by a specific sequence, and including the region 166aa to 235aa among the specific sequence; (b) a polypeptide formed from 70 or more continuous amino acids in a specific amino acid sequence, and including the region 166aa to 235aa in the specific amino acid sequence; and (c) a polypeptide having 80% or more of sequence homology with the polypeptide of (a) or (b).【課題】角膜疾患若しくは角膜損傷への予防、抑制又は治療作用を有する予防、抑制又は治療剤を提供する。【解決手段】以下の(a)~(c)からなる群から選ばれるいずれか一つのポリペプチドからなる領域を含むポリペプチドを有効成分として含有する角膜疾患若しくは角膜損傷の予防、抑制又は治療剤(a)特定配列に示されるアミノ酸配列中の連続する70個以上のアミノ酸から成り、特定のアミノ酸配列中の166aa~235aaの領域を含むポリペプチド、(b)特定のアミノ酸配列中の連続する70個以上のアミノ酸から成り、特定のアミノ酸配列中の166aa~235aaの領域を含むポリペプチド、(c)(a)又は(b)のポリペプチドと80%以上の配列相同性を有するポリペプチド。【選択図】なし