Claim 1: a method of factor VIII administered to a subject in need,Which comprises administering to the subject a Therapeutic dose of a Chimeric polypeptide comprising a portion of factor VIII and a second portion in a dose range at least approximately one and a half times longer than the range of doses required for equivalent dose A polypeptide consisting in that portion of the factor VIIIWhere this portion of factor VIII comprises the processing factor VIII, which has two Chains, which comprises a First Chain a heavy chain and a Second Chain comprising a light chain, where the first chain and the second Chain are associated with a Link.Claim: a composition comprising a Chimeric polypeptide that has activity of factor VIII, where at least approximately 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, AP Roximadamente approximately 96%, 97%, approximately 98% to 99%.Or about 100% of the polypeptide comprises a portion of factor VIII, which is the single Chain factor VIII, and a second portion.Where the single Chain factor VIII is at least 90% or 95% identical in amino acid sequence of the factor VIII is shown in Table 2 (without a Signal sequence of 20 amino acids in 1457 the SEQ ID no. 2 or 20 2351 amino acids to the SEQ ID no. 6).Claim 73: a method of treating a Bleeding condition comprises administering a therapeutically effective amount of the composition according to claim 39 - 72.Claim 81: a method of factor VIII in a population of patients to a higher level to 1% for at least a day, two days or three days which comprises administering a therapeutically effective amount to inject to the populationWhere is the therapeutically effective amount of at least 25 IU / kg and rfviiifc where at least 90% of the population maintains the minimum level of factor VIII in less than 1% or more.A method of Reclaiming 105: Prevent, reduce, or treating a Bleeding Episode in a subject comprising: (a) identify a Subject that has high levels of VWF by Measuring the level of VWF in plasma
