MARTINEZ GIL, ANA,DORRONSORO DIAZ, ISABEL,ALONSO CASCON, MERCEDES,PANIZO DEL PLIEGO, GEMA,FUERTES HUERTA, ANA,PEREZ PUERTO, MARIA JOSE,MEDINA PADILLA, MIGUEL
申请号：
CA2559740
公开号：
CA2559740C
申请日:
2005.04.04
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Provided are thiadiazolidine compounds of Formula (I) wherein R1 is an organicgroup having at least 8 atoms selected from C or O, which is not linkeddirectly to the N through a -C(O)- and comprising at least an aromatic ring,and their pharmaceutical compositions. These compounds are selective GSK-3inhibitors and have improved bioavailability. They are useful for thetreatment of GSK-3 mediated diseases, among others Alzheimer's disease, typeII diabetes, depression and brain injury.
