PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTION AND/OR TREATMENT OF BLOOD COAGULATION FACTOR XI (FXI) ABNORMALITIES COMPRISING MULTISPECIFIC ANTIGEN BINDING MOLECULE REPLACING FUNCTION OF BLOOD COAGULATION FACTOR VIII (FVIII)
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for use in the prevention and/or treatment of blood coagulation factor XI (FXI) abnormalities.SOLUTION: A pharmaceutical composition for use in the prevention and/or treatment of blood coagulation factor XI abnormalities comprising a multispecific antigen binding molecule replacing the function of blood coagulation factor VIII. The multispecific antigen binding molecule replacing the function of blood coagulation factor VIII is a bispecific antibody that binds to blood coagulation factor IX and/or active coagulation factor IX and blood coagulation factor X.EFFECT: The multispecific antigen binding molecule replacing the function of blood coagulation factor VIII, can be used not only for preventing and/or treating bleeding resulting from FVIII dysfunction in hemophilia A, acquired Hemophilia A, and von Willebrand disease, but can also be used for preventing and/or treating bleeding due to diseases related to an abnormality in blood coagulation factor XI by the coagulation promoting action thereof.SELECTED DRAWING: None【課題】血液凝固第XI因子（FXI）異常症の予防及び／又は治療に用いられる医薬組成物の提供。【解決手段】血液凝固第VIII因子の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第XI因子異常症の予防及び／又は治療に用いられる医薬組成物。血液凝固第ＶＩＩＩ因子の機能を代替する多重特異性抗原結合分子が、血液凝固第ＩＸ因子及び／又は活性型血液凝固第ＩＸ因子並びに血液凝固第Ｘ因子に結合する二重特異性抗体である、医薬組成物。【効果】FVIIIの機能を代替する多重特異性抗原結合分子は、FVIIIの機能不全に起因する血友病A、後天性血友病A及びフォンビルブランド病での出血に対する予防法及び/又は治療法として利用できるのみならず、その凝固促進活性から血液凝固第XI因子異常症での出血に対する予防法及び/又は治療法として利用できる。【選択図】なし
