METHODES DE TRAITEMENT DU CANCER ET/OU D'AMELIORATION DE LA SENSIBILITE A UN TRAITEMENT CONTRE LE CANCER PAR ACCROISSEMENT DE LA CHARGE DE MUTATIONS TUMORALES OU DES INDELS TUMORAUX

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专利权人:

MARK DAVID;VINCENT

发明人:

VINCENT, MARK DAVID

申请号：

CA3079907

公开号：

CA3079907A1

申请日:

2018.10.23

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Methods of treating cancer or enhancing sensitivity to cancer therapies, including immunotherapies by increasing tumor mutation burden, are provided. The methods use therapeutics directed against DNA polymerase proofreading and/or mismatch repair enzymes such as MLH1, MSH2, MSH6 or PMS2. The therapeutics can be used alone, in tandem or in combination with other cancer therapies, in particular with immunotherapies. Also provided are antisense therapeutics targeting DNA polymerase proofreading and/or mismatch repair enzymes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/