The invention relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.本發明關於製備經取代之三環化合物的新穎、可擴充的方法,其可在受試者中用於治療及/或預防HBV及/或HBV-HDV感染及相關症狀。