CAVITES TRIDIMENSIONNELLES D'IMMUNORECEPTEUR DE CELLULES DENDRITIQUES (DCIR), COMPOSES SE LIANT A CELLES-CI ET APPLICATIONS THERAPEUTIQUES ASSOCIEES A L'INHIBITION DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE DE TYPE 1 (VIH-1)
GILBERT, CAROLINE,TREMBLAY, MICHEL J.,LIN, SHENG-XIANG,AZZI, AREZKI,LAMBERT, ALEXANDRA
申请号：
CA2860015
公开号：
CA2860015A1
申请日:
2012.12.20
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention is concerned with compounds, pharmaceutical compositions, screening methods, and therapeutic methods for preventing or reducing a human immunodeficiency virus type-1 (HIV-1) infection and/or propagation associated with dendritic cell immunoreceptor (DCIR). Described herein are compounds which bind on at least one three-dimensional cavity of the DCIR, the cavity(ies) being involved in the interaction between HIV-1 and DCIR. Also described are screening methods for identifying active inhibitors and method of using such inhibitors for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus type-1 (HIV-1) binding, entry and/or replication in human cells.
