GRILLARI JOHANNES,SCHRAML ELISABETH,FORTSCHEGGER KLAUS,GRILLARI REGINA
申请号：
IN10686/CHENP/2012
公开号：
IN2012CN10686A
申请日:
2012.12.21
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to compositions comprising an inhibitor of a polynucleotide said polynucleotide to be inhibited being capable of decreasing or suppressing expression of FZD3 (Frizzled 3) or a biologically active derivative thereof for use in treating or preventing bone disorders and/or cardiovascular disorders. Such bone disorders comprise osteoporosis osteopenia bone fracture bone cancer as well as impaired bone homeostasis. Cardiovascular diseases to be treated by the compounds of the present invention may be selected from the group consisting of infarction stroke hypertension thrombosis vascular stenosis coronary syndromes vascular dementia heart failure renal failure stress related cardiovascular disorders and atherosclerosis. Preferred compounds to be used in these medical interventions are antagonistic compounds like nucleic acid molecules directed against miR 31 and derivatives thereof. Also the present invention relates to methods for diagnosing and compositions for use in diagnosing bone disorders and/or cardiovascular disorders. Compounds to be employed in these diagnostic methods and uses may be compounds (like primers and probes) that are capable of detecting such a polynucleotide that is capable of decreasing or suppressing expression of FZD3 or a biologically active derivative thereof. miR 31 is provided herein as a polynucleotide that is capable of decreasing or suppressing expression of FZD3.
