A low-dose CT imaging system and method that operates according to a pulsed X-ray emission scheme according to a predefined sequence of rotation angles of the X-ray source, along with image reconstruction algorithms to achieve high spatial and temporal resolution for CT scans. The systems and methods involve high speed switching (on the order of milliseconds) to generate pulsed exposure of X-ray radiation to the patient, reducing radiation dose by 4-8 fold, or more.