Ton LOGTENBERG,Mark THROSBY,Robert A. KRAMER,Rui Daniel PINTO,Cornelis A. DE KRUIF,Erwin HOUTZAGER
申请号：
US15866374
公开号：
US20180142003A1
申请日:
2018.01.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
