Class of pyrimidine derivative kinase inhibitors

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专利权人:

Hefei Institutes of Physical Science; Chinese Academy of Sciences

发明人:

LIU, Qingsong,LIU, Jing,LIANG, Xiaofei,WANG, Beilei,YU, Kailin,JIANG, Zongru,CHEN, Cheng,HU, Chen,WANG, Wenchao,ZOU, Fengming,LIU, Qingwang,LI, Feng,WANG, Wenliang,WANG, Li

申请号：

AU2017444054

公开号：

AU2017444054A1

申请日:

2017.12.26

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Provided is a kinase inhibitor, comprising a compound of formula I, or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite, or a prodrug thereof. Further provided are a pharmaceutical composition comprising the kinase inhibitor, and a use and a method for using the compound or the composition to inhibit the activity of wild-type FLT3, mutant FLT3-ITD, PDGFRα, and/or PDGFRβ kinases in a cell or a subject, and to prevent or treat a kinase-related disorder in a subject.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/