The invention provides a compound for use for treating, preventing or managing a condition associated with the activation, mutation and/or over -expression of one or more kinases, wherein if the condition is associated with Axl over -expression, it is also associated with the activation, mutation and/or over-expression of one or more other kinases, and wherein the compound has a structure according to formula (I) : wherein the symbols used in formula (I) are as defined herein.