A surgical instrument for minimally invasive surgery. The surgical instrument includes a manipulator, a proximal universal joint mounted to the manipulator, a tube mounted to the proximal joint, a distal universal joint mounted to the tube, and an end effector including at least one movable jaw mounted to the distal joint. Cables operatively couple the manipulator, proximal joint, and distal joints and concurrently operatively couple the manipulator and the end effector. Four cables may control two degrees of freedom of the distal joint and one degree of freedom of the jaw. Pivoting of the manipulator and a proximal yoke of the proximal joint results in a corresponding motion in a distal yoke of the distal joint. Actuation of an anchor in the manipulator results in operation of any moveable jaws in the end effector. The distal universal joint and the end effector may be integrated into one end segment part.
