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High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat
专利权人:
Watson Laboratories; Inc.
发明人:
NORDSIEK, Michael T.,BALAJI, Kodumudi S.
申请号:
AU2016200825
公开号:
AU2016200825A1
申请日:
2016.02.09
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2016200825A120160303.pdf#####ABSTRACT The present disclosure relates to mucoadhesive aqueous-based homogenous gel formulations of metronidazole (MTZ) for intravaginal application and their uses, for example to treat bacterial vaginosis. Particular compositions comprise high concentration, high dosage, 1% to 2% by weight formulations providing 60mg-Omg MTZ in a single application. These compositions also reduce the incidence of vulvovaginal candidiasis, which is a common occurrence following treatment for bacterial vaginosis. Compositions also comprise mucoadhesive gelling polymers and a solvent system comprising lower aromatic alcohols, lower alkylene diols and polyoxyalkeylenes, wherein the formulation can be free from solubility enhancers such as dextrins, cyclodextrins, niacin, niacinamide and surfactants.
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