James Lupton Hedrick,Alshakim Nelson,Chuan Yang,Yi Yan Yang
申请号：
US12646024
公开号：
US08470891B2
申请日:
2009.12.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of i) urea groups and ii) mixtures of urea groups and carboxylic acid groups. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.
